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The NEURAPRO-E Study: A comparison study of fish oil capsules and psychological therapy versus placebo capsules and psychological therapy in patients at risk of developing a psychotic disorder

Early treatment in Schizophrenia and other psychosis has been link to better outcomes. Given that subclinical psychotic symptoms may predict psychotic disorder and psychosis proneness in a population maybe related to the rate of psychotic disorder, intervention in at-risk individuals holds the promise of even better outcomes, with the potential to prevent full-blown psychotic disorders. A series of prospective studies validated criteria that are capable of identifying individuals with sub threshold symptoms at ultra-high risk (UHR) of psychosis.  Neuaoanatomical changes observed in UHR individuals who progress to psychotic disorder suggest an active biological process during this transition, raising the possibility that intervention might be indicated before expression of frank psychotic symptoms. Evidence had shown that omega-3 fatty acids may have neuroprotective properties and do not have clinical relevant adverse effects make them an ideal candidate for indicated prevention in young people at risk of psychosis.

Fish oils

This study aims to determine whether omega-3 fatty acids, along with cognitive behavioural case management, can reduce the incidence of the development of a psychotic disorder in patients who are ‘at risk’ of developing such a disorder.

This is an international, multi-center trial, involving 9 countries (including Singapore) sponsored by ORYGEN Research Centre (Australia). The Singapore study team study is led by A/Prof Swapna Verma.

Recruitment has commenced since 3rd Quarter of 2011.

This study is sponsored by the ORYGEN Research Centre, Australia.

Principal Investigator:

  • A/Prof Swapna Verma, Institute of Mental Health


  • A/Prof Chong Siow Ann, Institute of Mental Health
  • Dr Mythily Subramaniam, Institute of Mental Health
  • Dr Sujatha Rao, Institute of Mental Health
  • Dr Sutapa Basu, Institute of Mental Heal
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