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Biomarkers in Psychosis

The practice of psychiatry is dependent on observations and obtained accounts to make diagnoses and monitor effects of treatment. This programme utilizes available technological advancements to identify biomarkers of clinical utility.

Blood presented an easily accessible tissue on which we based our first studies. We adopted an “Omics” approach to elucidate a blood-based molecular signature, and to examine the relationship with clinical symptomatology and responses. Blood transcriptomes and lipidomes were profiled using microarray and mass spectrometry, respectively, to identify an expression signature unique to patients with schizophrenia.


A collaborative study team led by Dr Jimmy Lee together with clinicians from the Institute of Mental Health, and scientists from the National University of Singapore is involved in this effort.

This study is funded by grants from the National Medical Research Council (NMRC), Singapore, and the National Healthcare Group (NHG), Singapore.

Principal Investigator:

  • Dr Jimmy Lee, Institute of Mental Health

Co- Investigators:

  • A/Prof Chong Siow Ann, Institute of Mental Health
  • A/Prof Tih Shih Lee, Duke-NUS Graduate Medical School
  • Asst/Prof Goh Liang Kee, Duke-NUS Graduate Medical School
  • A/Prof Markus Wenk, Centre for Life Sciences, National University of Singapore
  • Asst/Prof Agus Salim, Saw Swee Hock School of Public Health, National University of Singapore 
A member of National Healthcare Group ISO   Comm Chest Award Bronze